Dynamic test as a method of choice for determination of the burst release of Zn from zinc doped bioactive glasses
KANKOVÁ H. 1, BUNOVÁ L. 1, NESCÁKOVÁ Z. 1, MICHÁLEK M. 1, GALUSEK D. 1,2, GALUSKOVÁ D. 1
1 Centre for Functional and Surface Functionalized Glass, Alexander Dub?ek University of Tren?ín, Tren?ín, Slovakia; 2 Joint Glass Centre of the IIC SAS, TnUAD and FChPT STU, Tren?ín, Slovakia
Zinc doped bioactive glasses prepared by conventional melting and sol-gel technique were tested in simulated body fluid (SBF) to quantitatively determine zinc ion release at the early stage of dissolution of bioactive glass. The analysis of the leaching solution was performed in a flow-through arrangement, with the reaction cell connected directly to the nebulizer of the ICP OES. Direct monitoring in the first minutes of contact of the glass with SBF contributed to determination of the immediate quantity of zinc leached from the glass and confirmed burst release of zinc from material with a maximum after ~2 minutes of contact with the SBF.
Possible formation of zinc silicate and zinc phosphate as alteration products precipitating from SBF solution along with hydroxyapatite was evaluated using the PHREEQC modelling code.
Acknowledgment:
This item is a part of dissemination activities of project FunGlass. This project has received funding from the European Union´s Horizon 2020 research and innovation programme under grant agreement No 739566. The authors would like to acknowledge VEGA 01/0191/20 grant.