PEEK and its composites (i.e. carbon-fiber-reinforced PEEK noted CFR-PEEK) are increasingly used to replace metals for the production of medical devices, especially for spinal implants. To choose using PEEK implants is related to material biocompatibility, radiolucency, and mechanical properties similar to that of naturalbone. However, PEEK implants are biologically inert and hydrophobic, which reduces their integration with bone tissue after implantation. In the frame of the ANR project Ca-PEEK (ANR-22-CE19-0025), the PEEK surface will be modified with a functionalized biomimetic apatite coating deposited by cold spray to improve the osseointegration of PEEK implants. To achieve this goal, PEEK surface needs to be tailored to promote adhesion of cold sprayed hydroxyapatite coating. In the present study, a wide variety of surface modification techniques have been applied to modify the surface properties of PEEK for better coating anchoring. Since PEEK is resistant to most chemicals, sulfonation was the only wet chemical treatment that has been evaluated. In contrast, several physical techniques have been implemented such as sandblasting, laser or plasma treatments to modify the topography of the PEEKsurface and potentially its chemistry. The operating conditions and/or protocols that were tested with these surface modification techniques will be detailed in the poster.The topographical evolutions of the modified PEEK surfaces were checked using S-NeoX optical profilometer. For instance, sand blasting induces an increase of Ra from a few μm to over 10 μm together with an embedding of the HAP used as sandblasting media depending on the strategy. All strategies affect the topography in various ways and levels. Physicochemical characteristics of the neat and modified surfaces were determined implementing FTIR and Raman spectroscopies, SEM EDS analysis, XRD studies and specific surface analysis like XPS. Finally, preliminary results regarding the ability to anchor a HAP cold spray coating have been achievedand will be shown to draw conclusions on the effectiveness of the pre-treatment.